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Ultra-rapid metabolism occurs when a person has a particular variant of the gene for a liver enzyme called CYP2D6. As with other opiates, a serious probable adverse reaction Promethazine w codeine is respiratory depression. Heroin and other opioids are depressants. Dependence on heroin can be psychological, physical or both. The dosage at which codeine is safe is from 10-60mg at once. Heroin is usually a mixture of pure heroin and other substances, such as caffeine and sugar. However, many painkillers promethazine w codeine are available to purchase over- the-counter OTC from a pharmacy, and it is usually safe to drink alcohol while taking them, as long as you do not drink more than your recommended daily amount, and you take the painkillers at the correct dosage. Patients and parents need to learn about the lack of proven antitussive effects and the potential risks of these products.